Hydrochloric Acid → HCID 15077478、化合物

HRID 1650882

反応式

HRID 1650882 の反応式
[CH2:1]([C:3]1[CH:4]=[N:5][C:6]([CH3:14])=[C:7]([CH:13]=1)[C:8]([O:10]CC)=[O:9])[CH3:2].[OH-].[Na+].Cl>CO.O>[CH2:1]([C:3]1[CH:4]=[N:5][C:6]([CH3:14])=[C:7]([CH:13]=1)[C:8]([OH:10])=[O:9])[CH3:2]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 144366265-Ethyl-2-methyl-nicotinic acid ethyl ester

生成物 1

HCID 15077478HCID 15077478、化合物収率 1.4%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A solution of 260 g of ethyl 5-ethyl-2-methylnicotinate 81.34 mol) in 250 mL methanol is treated in 1 portion with a solution of 80 g of sodium hydroxide (2 mol) in 1 L water. The reaction is stirred at room temperature for 2 days, then concentrated in vacuo to a volume of about 700 mL, and acidified with 167 mL of concentrated hydrochloric acid (2 moles). The precipitated solid is filtered, washed with cold water, and dried in vacuo at 75° C. to afford 184 g of the title product, mp 218°-220° C.

後処理

  1. concentrationconcentrated in vacuo to a volume of about 700 mL
  2. filtrationThe precipitated solid is filtered
  3. washwashed with cold water
  4. customdried in vacuo at 75° C.

出典と根拠

ORDレコード
ord-8d9cb089dd3d4958bbc5ae0ad6629a77
出典データセット
uspto-grants-1990_05
特許番号
US04925944

関連ノート

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