Ethyl 2-methyl-6-nitrobenzoate → Ethyl 2-amino-6-methylbenzoate
反応式
[CH3:1][C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:6]([N+:13]([O-])=O)[CH:5]=[CH:4][CH:3]=1>C(O)(=O)C.C(O)C.O.[Fe]>[NH2:13][C:6]1[CH:5]=[CH:4][CH:3]=[C:2]([CH3:1])[C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9]参加物
6
実験手順
A reaction mixture of 185 g of ethyl 6-methyl-2-nitrobenzoate and 176 g of powdered iron in 343 mL of glacial acetic acid and 2200 mL of ethanol was heated at reflux for 5 hours. The reaction mixture was allowed to cool, diluted with excess water and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, filtered and concentrated to an orange oil 148.3 g.
後処理
- temperaturewas heated
- temperatureat reflux for 5 hours
- temperatureto cool
- extractionextracted with ethyl acetate
- dry with materialThe organic layer was dried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated to an orange oil 148.3 g
出典と根拠
- ORDレコード
- ord-30b7f14ea9e4410f82ab57807a24ad3a
- 出典データセット
- uspto-grants-1990_05
- 特許番号
- US04927453
反応ノート
読み込み中…