Acetic Acid → Methyl Picolinimidate
反応式
ClC1C=CC=CC=1O[C:5]1[N:10]=[C:9]([C:11]#[N:12])[CH:8]=[CH:7][CH:6]=1.[Na].[C:18](O)(=[O:20])C>C[O-].[Na+].CO>[N:10]1[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=1[C:11](=[NH:12])[O:20][CH3:18]参加物
6
実験手順
6-o-Chlorophenoxy-2-cyanopyridine (10 g) was dissolved in a solution of sodium methoxide in methanol prepared from methanol (150 ml) and metallic sodium (0.50 g). After the solution was left to stand overnight, acetic acid (1.3 g) was added thereto, followed by concentration under reduced pressure. The resulting residue was dissolved in ether (200 ml) and insoluble materials were filtered out. The filtrate was concentrated under reduced pressure to obtain methyl 2-picoline imidate derivative.
後処理
- waitAfter the solution was left
- concentrationfollowed by concentration under reduced pressure
- dissolutionThe resulting residue was dissolved in ether (200 ml)
- filtrationinsoluble materials were filtered out
- concentrationThe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-d4ad2367ba5440c8bdc81ab8571889d4
- 出典データセット
- uspto-grants-1990_05
- 特許番号
- US04927827
反応ノート
読み込み中…