Borane → HCID 15097577、化合物

HRID 1651254ノート

反応式

HRID 1651254 の反応式
[C:1]([C:6](=[C:11]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH3:27])[CH:21]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=1)[CH2:7][C:8](O)=[O:9])([O:3][CH2:4][CH3:5])=[O:2].B>O1CCCC1>[CH2:4]([O:3][C:1](=[O:2])[C:6]([CH2:7][CH2:8][OH:9])=[C:11]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH3:27])[CH:21]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=1)[CH3:5]

参加物

4

反応物 2

HCID 6331BoraneHCID 23051607HCID 23051607、化合物

生成物 1

HCID 15097577HCID 15097577、化合物収率 78.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

As described in Example 135, a solution of 3-carboethoxy-4,4-bis(3-methoxyphenyl)-3-butenoic acid (20.5 g) in dry tetrahydrofuran (100 mL) was treated with a solution of 1M borane in tetrahydrofuran (57 mL) and the reaction was stirred at room temperature overnight. After the usual work up, the crude product was purified by HPLC (diethyl etherhexane; 65:35) to provide 15.4 g of 2-hydroxyethyl-3,3-bis(3-methoxyphenyl)-2-propenoic acid ethyl ester, mp 102.5°-103.5° C. Anal. Calcd for C19H20O3 : C, 77.00; H, 6.80 Found: C, 77.12; H, 6.69

後処理

  1. customAfter the usual work up, the crude product was purified by HPLC (diethyl etherhexane; 65:35)

出典と根拠

ORDレコード
ord-77f40ba2a57a43afb8ea644b4d502ad8
出典データセット
uspto-grants-1990_05
特許番号
US04927838

反応ノート

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