Sodium Hydroxide → (E)-3-(6-methoxy-3-pentylbenzofuran-2-yl)-2-propenoic acid

HRID 1651271ノート

反応式

HRID 1651271 の反応式
C[O:2][C:3](=[O:22])/[CH:4]=[CH:5]/[C:6]1[O:7][C:8]2[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:9]=2[C:10]=1[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].[OH-].[Na+]>CO>[CH3:21][O:20][C:18]1[CH:17]=[CH:16][C:9]2[C:10]([CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[C:6](/[CH:5]=[CH:4]/[C:3]([OH:22])=[O:2])[O:7][C:8]=2[CH:19]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 14742791(E)-3-(6-methoxy-3-pentylbenzofuran-2-yl)-2-propenoic acid methyl ester

生成物 1

HCID 14742803(E)-3-(6-methoxy-3-pentylbenzofuran-2-yl)-2-propenoic acid収率 88.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

As in Example 112, (E)-3-(6-methoxy-3-pentylbenzofuran-2-yl)-2-propenoic acid methyl ester (4.25 g) in methanol (25 mL) was treated with 2N sodium hydroxide solution (15 mL) at reflux for 1.25 hours. The crude reaction product was crystallized from ethyl acetate to provide 3.6 g of (E)-3-(6-methoxy-3-pentylbenzofuran-2-yl)-2-propenoic acid, mp 146°-147° C. Anal. Calcd for C17H20O4 : C, 70.81; H, 6.99 Found: C, 70.51; H, 6.89

後処理

  1. temperatureat reflux for 1.25 hours
  2. customThe crude reaction product
  3. customwas crystallized from ethyl acetate

出典と根拠

ORDレコード
ord-3550023565dc417f8ed008453e00080e
出典データセット
uspto-grants-1990_05
特許番号
US04927838

反応ノート

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