Ammonia → 1-(6-Amino-5-chloropyridin-3-YL)ethan-1-one
反応式
Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9](=[O:11])[CH3:10])=[CH:4][N:3]=1.[NH3:12]>O1CCCC1>[NH2:12][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9](=[O:11])[CH3:10])=[CH:4][N:3]=1参加物
4
実験手順
1.9 g (10 mmol) of 2,3-dichloro-5-acetylpyridine are heated at 170° C. in a mixture of 80 ml of tetrahydrofuran and 20 ml of concentrated aqueous ammonia in an autoclave for 8 hours. After the tetrahydrofuran has been evaporated off, the residue is diluted with water and the mixture is brought to pH 5 and extracted with ethyl acetate.
後処理
- customAfter the tetrahydrofuran has been evaporated off
- additionthe residue is diluted with water
- extractionextracted with ethyl acetate
出典と根拠
- ORDレコード
- ord-747cba35392a4e5e88da93554cb3c296
- 出典データセット
- uspto-grants-1990_05
- 特許番号
- US04927938
反応ノート
読み込み中…