p-Toluenesulfonic acid → 1-Piperidinebutanoic acid, 4-((4-chlorophenyl)-2-pyridinylmethoxy)-, ethyl ester, mono(4-methylbenzenesulfonate)

HRID 1651560

反応式

HRID 1651560 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=2)[O:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1.[C:30]1([CH3:40])[CH:35]=[CH:34][C:33]([S:36]([OH:39])(=[O:38])=[O:37])=[CH:32][CH:31]=1>>[C:30]1([CH3:40])[CH:31]=[CH:32][C:33]([S:36]([OH:39])(=[O:37])=[O:38])=[CH:34][CH:35]=1.[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=2)[O:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:12][CH2:11]2)=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 6101p-Toluenesulfonic acidHCID 3079389rac Bepotastine Ethyl Ester

生成物 1

HCID 30793881-Piperidinebutanoic acid, 4-((4-chlorophenyl)-2-pyridinylmethoxy)-, ethyl ester, mono(4-methylbenzenesulfonate)収率 91.4%

実験手順

5.33 g (12.78 mmol) of the ethyl ester obtained in Example 26 and 2.43 g (12.78 mmol) of p-toluenesulfonic acid were treated in the same procedure as described in Example 2 to give 6.88 g (91%) of ethyl 4-[4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]butanoate p-toluenesulfonate.

出典と根拠

ORDレコード
ord-4d93dfd2026b4269b89853f5b29f94ef
出典データセット
uspto-grants-1990_05
特許番号
US04929618

関連ノート

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