Dimethylformamide → HCID 14770848、化合物

HRID 1651580ノート

反応式

HRID 1651580 の反応式
[NH2:1][CH:2]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]([F:16])=[CH:14][C:10]([C:11]([OH:13])=O)=[C:9]([F:17])[CH:8]=2)[CH2:3]1.[C:18](Cl)(=O)[C:19](Cl)=[O:20].CN(C)C=O.C(Cl)[Cl:30]>>[C:19]([NH:1][CH:2]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]([F:16])=[CH:14][C:10]([C:11]([Cl:30])=[O:13])=[C:9]([F:17])[CH:8]=2)[CH2:3]1)(=[O:20])[CH3:18]

参加物

5

反応物 4

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 14770846HCID 14770846、化合物

生成物 1

HCID 14770848HCID 14770848、化合物

実験手順

A mixture of 14.2 g (50 mmole) of 4-[3-(amino)cyclopentyl]-2,5-difluorobenzoic acid in 200 ml of methylene chloride was treated with 6.4 g (50 mmol) of oxalyl chloride and 0.5 ml of dimethylformamide. The reaction mixture was stirred at room temperature for 18 hours and the solvent removed in vacuo. The residue was triturated with toluene which was also removed in vacuo. The residue was used without further purification.

後処理

  1. customthe solvent removed in vacuo
  2. customThe residue was triturated with toluene which
  3. customwas also removed in vacuo
  4. customThe residue was used without further purification

出典と根拠

ORDレコード
ord-3d6f2e382b7c4386a165a848e5105a56
出典データセット
uspto-grants-1990_05
特許番号
US04929613

反応ノート

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