Malonic Acid → 2-Methylbenzylidenemalonic acid
反応式
[CH3:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[C:10]([OH:16])(=[O:15])[CH2:11][C:12]([OH:14])=[O:13]>>[CH3:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[C:11]([C:10]([OH:16])=[O:15])[C:12]([OH:14])=[O:13]参加物
3
反応条件
- 温度
- 90 °C
実験手順
Combine 2-methylbenzaldehyde (39.6 g, 0.33 mol) and malonic acid (34.3 g, 0.33 mol). Heat at 90° C. for one hour, add 3.9 g of the aldehyde, and heat 6 hr. at 90°. Allow to cool, partition between diethyl ether and 1N NaOH, acidify the aqueous layer, filter off the solid, wash and dry to give the title compound as a beige solid, m.p. 197°-200°.
後処理
- temperatureheat 6 hr
- customat 90°
- temperatureto cool
- custompartition between diethyl ether and 1N NaOH
- filtrationfilter off the solid
- washwash
- customdry
出典と根拠
- ORDレコード
- ord-1868c05858394c2c9370ed101e8006ec
- 出典データセット
- uspto-grants-1990_05
- 特許番号
- US04929641
反応ノート
読み込み中…