Piperidine → HCID 178517240、化合物

反応式

C1CCNCC1.O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1>C1CN2CCN1CC2.COCCOC.CS(C)=O.O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccccc21.[Cl][Ni][Cl]>O=C1Nc2ccc(N3CCCCC3)cc2C(C#CC2CC2)(C(F)(F)F)O1

参加物

反応条件

温度: 55 °C

後処理

additionThe samples was moved from a 1536 well plate into a 384 well plate. The 384 well plate contained 75 microliter of 1% Acetic acid in DMSO solution with 0.003M trimethoxybenzene. The reaction plate was rinsed three times with the same solution to make a total addition volume of ~90 microliters
aliquot25 microliter of quenched reaction mixture was taken
additionTo the 25 microliter aliquot 50 microliter of DMSO was added. If the original reaction concentration was 0.05 M (wrt limiting reagent). This would make a final analytical concentration of 0.36 mM which is in line with typical analytical concentrations from this group.

出典と根拠

ORDレコード: ord-5d1b49fbfb694abf91120dc2b28bd4f8
出典データセット: Nano CN PhotoChemistry Informers Library
DOI: 10.1021/acs.accounts.0c00760
元リンク: 出典を表示

反応ノート

読み込み中…

参加物

反応物 2

HCID 8082Piperidine

HCID 64139Efavirenz

生成物 1

HCID 178517240HCID 178517240、化合物収率 0%

試薬・触媒・溶媒 4

HCID 9237Dabco触媒

HCID 16850Fluorescein触媒

HCID 15773433Dichloronickel;1,2-dimethoxyethane触媒

HCID 679Dimethyl Sulfoxide溶媒3 回

反応条件

温度: 55 °C

後処理

additionThe samples was moved from a 1536 well plate into a 384 well plate. The 384 well plate contained 75 microliter of 1% Acetic acid in DMSO solution with 0.003M trimethoxybenzene. The reaction plate was rinsed three times with the same solution to make a total addition volume of ~90 microliters
aliquot25 microliter of quenched reaction mixture was taken
additionTo the 25 microliter aliquot 50 microliter of DMSO was added. If the original reaction concentration was 0.05 M (wrt limiting reagent). This would make a final analytical concentration of 0.36 mM which is in line with typical analytical concentrations from this group.

出典と根拠

ORDレコード: ord-5d1b49fbfb694abf91120dc2b28bd4f8
出典データセット: Nano CN PhotoChemistry Informers Library
DOI: 10.1021/acs.accounts.0c00760
元リンク: 出典を表示

反応ノート

読み込み中…