Piperidine → HCID 178470271、化合物

HRID 1651939

反応式

HRID 1651939 の反応式
C1CCNCC1.CCOC(=O)c1ncn2c1CN(C)C(=O)c1cc(Br)ccc1-2>C1CN2CCN1CC2.COCCOC.CS(C)=O.O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccccc21.[Cl][Ni][Cl]>CCOC(=O)c1ncn2c1CN(C)C(=O)c1cc(N3CCCCC3)ccc1-2

参加物

7

反応物 2

HCID 8082PiperidineHCID 10737466Ethyl 8-bromo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate

生成物 1

HCID 178470271HCID 178470271、化合物収率 9.115%

試薬・触媒・溶媒 4

HCID 9237Dabco触媒HCID 16850Fluorescein触媒HCID 15773433Dichloronickel;1,2-dimethoxyethane触媒HCID 679Dimethyl Sulfoxide溶媒3 回

反応条件

温度
55 °C

後処理

  1. additionThe samples was moved from a 1536 well plate into a 384 well plate. The 384 well plate contained 75 microliter of 1% Acetic acid in DMSO solution with 0.003M trimethoxybenzene. The reaction plate was rinsed three times with the same solution to make a total addition volume of ~90 microliters
  2. aliquot25 microliter of quenched reaction mixture was taken
  3. additionTo the 25 microliter aliquot 50 microliter of DMSO was added. If the original reaction concentration was 0.05 M (wrt limiting reagent). This would make a final analytical concentration of 0.36 mM which is in line with typical analytical concentrations from this group.

出典と根拠

ORDレコード
ord-809b218efff54917a28b57d2acb7caa8
出典データセット
Nano CN PhotoChemistry Informers Library
元リンク
出典を表示

関連ノート

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