Piperidine → HCID 178431711、化合物

反応式

C1CCNCC1.CC1(C)OC(=O)C(Oc2ccc(Br)cn2)=C1c1ccc(S(C)(=O)=O)cc1>C1CN2CCN1CC2.COCCOC.CS(C)=O.Fc1cc(F)c(-c2ccccn2)[c]([Ir]([c]2cc(F)cc(F)c2-c2ccccn2)[c]2cc(F)cc(F)c2-c2ccccn2)c1.[Cl][Ni][Cl]>CC1(C)OC(=O)C(Oc2ccc(N3CCCCC3)cn2)=C1c1ccc(S(C)(=O)=O)cc1

参加物

反応条件

温度: 55 °C

後処理

additionThe samples was moved from a 1536 well plate into a 384 well plate. The 384 well plate contained 75 microliter of 1% Acetic acid in DMSO solution with 0.003M trimethoxybenzene. The reaction plate was rinsed three times with the same solution to make a total addition volume of ~90 microliters
aliquot25 microliter of quenched reaction mixture was taken
additionTo the 25 microliter aliquot 50 microliter of DMSO was added. If the original reaction concentration was 0.05 M (wrt limiting reagent). This would make a final analytical concentration of 0.36 mM which is in line with typical analytical concentrations from this group.

出典と根拠

ORDレコード: ord-845702027a464578b202c4ce5a79c3d4
出典データセット: Nano CN PhotoChemistry Informers Library
DOI: 10.1021/acs.accounts.0c00760
元リンク: 出典を表示

反応ノート

読み込み中…

参加物

反応物 2

HCID 8082Piperidine

HCID 99328283-((5-Bromopyridin-2-yl)oxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one

生成物 1

HCID 178431711HCID 178431711、化合物収率 3.851%

試薬・触媒・溶媒 4

HCID 9237Dabco触媒

HCID 15773433Dichloronickel;1,2-dimethoxyethane触媒

HCID 178505916Tris[2-(2-pyridinyl)-3,5-difluorophenyl] iridium(III)触媒

HCID 679Dimethyl Sulfoxide溶媒3 回

反応条件

温度: 55 °C

後処理

additionThe samples was moved from a 1536 well plate into a 384 well plate. The 384 well plate contained 75 microliter of 1% Acetic acid in DMSO solution with 0.003M trimethoxybenzene. The reaction plate was rinsed three times with the same solution to make a total addition volume of ~90 microliters
aliquot25 microliter of quenched reaction mixture was taken
additionTo the 25 microliter aliquot 50 microliter of DMSO was added. If the original reaction concentration was 0.05 M (wrt limiting reagent). This would make a final analytical concentration of 0.36 mM which is in line with typical analytical concentrations from this group.

出典と根拠

ORDレコード: ord-845702027a464578b202c4ce5a79c3d4
出典データセット: Nano CN PhotoChemistry Informers Library
DOI: 10.1021/acs.accounts.0c00760
元リンク: 出典を表示

反応ノート

読み込み中…