化工社化工社 化学情報印刷レポート · 研究参考用
Water → 8-(3-Trifluoromethylphenyl)-6-(4-trifluoromethylphenyl)pyrido[2,3-d]pyridazin-5-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 4-(Trifluoromethyl)phenylhydrazine | HCID 136200 | — |
| 反応物 | 2-(3-Trifluoromethylbenzoyl)nicotinic acid | HCID 20078895 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 8-(3-Trifluoromethylphenyl)-6-(4-trifluoromethylphenyl)pyrido[2,3-d]pyridazin-5-one | HCID 20078892 | — |
反応手順
A suspension of 2-(3-trifluoromethylbenzoyl)nicotinic acid (1.5 g) and 4-trifluoromethylphenylhydrazine (1.34 g) in toluene was stirred at reflux temperature for 3 hours (water was removed azeotropically from the mixture).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05405826 |
| 出典データセット | uspto-grants-1995_04 |
| ORD ID | ord-64ecef6e5d66456da5d6e3b2af2269ae |
| 出典メモ | uspto-grants-1995_04 |