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Hydrazine hydrate (1:1) → 8-(3-Trifluoromethylphenyl)pyrido[2,3-d]pyridazin-5-(6H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | 2-(3-Trifluoromethylbenzoyl)nicotinic acid | HCID 20078895 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 8-(3-Trifluoromethylphenyl)pyrido[2,3-d]pyridazin-5-(6H)-one | HCID 20078863 | — |
反応手順
A mixture of 2-(3-trifluoromethylbenzoyl)nicotinic acid (1.5 g) and hydrazine hydrate (0.4 g) in ethanol was heated at the reflux temperature for 5 hours. On cooling and reduction of the volume of solvent by evaporation, a precipitate formed which was collected by filtration, to give the title compound as a white solid, 1.08 g, m.p. 210°-215° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05405826 |
| 出典データセット | uspto-grants-1995_04 |
| ORD ID | ord-9fe5b2bec79f4dce9192e2e36735ee5b |
| 出典メモ | uspto-grants-1995_04 |