Hydrochloric Acid → 2-Methyl-4-(trifluoromethyl)-3-furancarboxylic acid
反応式
[CH3:1][C:2]1[O:3][CH:4]=[C:5]([C:12]([F:15])([F:14])[F:13])[C:6]=1[C:7]([O:9]CC)=[O:8].C(O)C.[OH-].[Na+].Cl>O>[CH3:1][C:2]1[O:3][CH:4]=[C:5]([C:12]([F:14])([F:13])[F:15])[C:6]=1[C:7]([OH:9])=[O:8]参加物
6
実験手順
18 g of the product of Stage B were refluxed for 2 and a half hours in 42 ml of water and 126 ml of ethanol in the presence of 3.55 g of sodium hydroxide. The mixture was allowed to return to room temperature and 2N hydrochloric acid was added to neutrality. The mixture was partially concentrated and 2N sodium hydroxide solution was added. The mixture was extracted with isopropyl ether and the solvent was evaporated to obtain 14.25 g of the expected product melting at 140° C.
後処理
- customto return to room temperature
- concentrationThe mixture was partially concentrated
- addition2N sodium hydroxide solution was added
- extractionThe mixture was extracted with isopropyl ether
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-db2556f9bd474c59a44562813949abb7
- 出典データセット
- uspto-grants-1995_04
- 特許番号
- US05405865
反応ノート
読み込み中…