ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Potassium sodium tartarate → N-(4-(4-(Ethyl(4,4-dimethylpentyl)amino)-1-hydroxybutyl)phenyl)methanesulfonamide

HRID 1654294
ノート
印刷プレビュー

反応式

HRID 1654294 の反応式
[CH2:1]([N:3]([C:20](=O)[CH2:21][CH2:22][C:23]([CH3:26])([CH3:25])[CH3:24])[CH2:4][CH2:5][CH2:6][CH:7]([C:9]1[CH:14]=[CH:13][C:12]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:11][CH:10]=1)[OH:8])[CH3:2].[H-].[H-].[H-].[H-].[Li+].[Al+3].C(C(C(C([O-])=O)O)O)([O-])=O.[Na+].[K+]>C1COCC1>[CH2:1]([N:3]([CH2:20][CH2:21][CH2:22][C:23]([CH3:24])([CH3:26])[CH3:25])[CH2:4][CH2:5][CH2:6][CH:7]([C:9]1[CH:10]=[CH:11][C:12]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:13][CH:14]=1)[OH:8])[CH3:2]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 9855836Potassium sodium tartarateHCID 20080099N-(4-(4-(ethyl(4,4-dimethylpentanoyl)amino)-1-hydroxybutyl)phenyl)methanesulfonamideHCID 21226445Aluminium lithium hydride

生成物 1

HCID 15294455N-(4-(4-(Ethyl(4,4-dimethylpentyl)amino)-1-hydroxybutyl)phenyl)methanesulfonamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒
3 回

実験手順

A solution of the product from Step I (4.4 g, 0.0115 mol) in THF (46.4 ml) was added dropwise during 45 minutes, under nitrogen to a stirred, ice cold mixture of a 1M solution of LiAlH4 in THF (24.0 ml) and THF (24 ml). The mixture was kept in the ice bath for 45 minutes and then treated slowly with a saturated aqueous solution of potassium sodium tartrate (24.4 ml). This mixture was stirred for 30 minutes and extracted with EtOAc. The extracts were washed with water and brine, dried (MgSO4) and concentrated. The residue was chromatographed on silica gel with 5-10% MeOH--CHCl3. The product was dissolved in Et2O, washed with NaHCO3, dried (MgSO4) and concentrated to give 2.96 of the titled compound. The FAB mass spectrum had m/z 385 (M+H)+. Theory for C20H37N2O3S: 385.2525; measured.: 385.2546.

後処理

  1. extractionextracted with EtOAc
  2. washThe extracts were washed with water and brine
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated
  5. customThe residue was chromatographed on silica gel with 5-10% MeOH
  6. dissolutionThe product was dissolved in Et2O
  7. washwashed with NaHCO3
  8. dry with materialdried (MgSO4)
  9. concentrationconcentrated

出典と根拠

ORDレコード
ord-a2f269729b65413ca26f17e89f1a5470
出典データセット
uspto-grants-1995_04
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05405997

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート