Nitric Acid → HCID 19437878、化合物

HRID 1654479ノート

反応式

HRID 1654479 の反応式
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]2[N:6]([CH:10]([CH3:12])[CH3:11])[C:7](=[O:9])[NH:8][C:4]=2[CH:3]=1.[N+:15]([O-])([OH:17])=[O:16]>ClC1C=CC=CC=1Cl>[Cl:1][C:2]1[C:14]([N+:15]([O-:17])=[O:16])=[CH:13][C:5]2[N:6]([CH:10]([CH3:12])[CH3:11])[C:7](=[O:9])[NH:8][C:4]=2[CH:3]=1

参加物

4

反応物 2

HCID 944Nitric AcidHCID 108461602H-Benzimidazol-2-one, 5-chloro-1,3-dihydro-1-(1-methylethyl)-

生成物 1

HCID 19437878HCID 19437878、化合物収率 84.5%

試薬・触媒・溶媒 1

HCID 72391,2-Dichlorobenzene溶媒

反応条件

温度
60 °C

実験手順

5-Chloro-1-isopropylbenzimidazol-2-one (4.0 g) was dissolved in o-dichlorobenzene (80 ml) and thereto was added dropwise 70% nitric acid (2.0 g). The mixture was stirred at 60° C. for 1 hour and left to stand for cooling. The precipitated crystal was separated by filtration and washed with diethyl ether and water to give 5-chloro-1-isopropyl-6-nitrobenzimidazol-2-one (4.1 g). A part of the obtained product was recrystallized from ethanol, which showed the following physical properties:

後処理

  1. waitleft
  2. temperaturefor cooling
  3. customThe precipitated crystal was separated by filtration
  4. washwashed with diethyl ether and water

出典と根拠

ORDレコード
ord-22424505da9443a8ae71d811312ab1b9
出典データセット
uspto-grants-1995_04
特許番号
US05407936

反応ノート

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