Toluene → N-[3-(4-Methoxybenzyloxy)pyrid-2-yl]-N'-phenylthiourea

HRID 1654880ノート

反応式

HRID 1654880 の反応式
[NH2:1][C:2]1[C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[C:18]1([N:24]=[C:25]=[S:26])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.C1(C)C=CC=CC=1>C(OCC)C>[CH3:17][O:16][C:13]1[CH:14]=[CH:15][C:10]([CH2:9][O:8][C:7]2[C:2]([NH:1][C:25]([NH:24][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[S:26])=[N:3][CH:4]=[CH:5][CH:6]=2)=[CH:11][CH:12]=1

参加物

5

反応物 3

HCID 1140TolueneHCID 7673Phenyl IsothiocyanateHCID 27283893-[(4-Methoxybenzyl)oxy]pyridin-2-amine

生成物 1

HCID 20076982N-[3-(4-Methoxybenzyloxy)pyrid-2-yl]-N'-phenylthiourea

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 2-amino-3-(4-methoxybenzyloxy)pyridine (1.91 g, 0.0083 mol), phenyl isothiocyanate (1.4 g, 0.01 mol) and toluene (10 ml) was refluxed for 3.5 hours, then cooled and treated with diethyl ether to induce crystallisation of the product. Yield 2.18 g (72%), m.p. 123°-125 ° C.

後処理

  1. temperaturewas refluxed for 3.5 hours
  2. temperaturecooled
  3. customcrystallisation of the product

出典と根拠

ORDレコード
ord-a2681fa8ea7a4ddeb3f2ce3dfa836485
出典データセット
uspto-grants-1995_04
特許番号
US05409943

反応ノート

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