Ammonia → HCID 178512029、化合物

HRID 1654912ノート

反応式

HRID 1654912 の反応式
[F:1][C:2]1[CH:26]=[C:25]([F:27])[CH:24]=[C:23]([F:28])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=S)=[N:8][CH:9]=[CH:10][CH:11]=1.[NH3:29]>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:26]=[C:25]([F:27])[CH:24]=[C:23]([F:28])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=[NH:29])=[N:8][CH:9]=[CH:10][CH:11]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 200770093-(2,4,6-Trifluorobenzyloxy)pyrid-2-yl-N'-(4-chlorophenyl)thiourea

生成物 1

HCID 178512029HCID 178512029、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A mixture of yellow mercuric oxide (0.74 g, 0.036 mol), N-[3-(2,4,6-trifluorobenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea (1.27 g, 0.003 mol) and methanolic ammonia solution (40 ml) was stirred for 1 day at room temperature. The solvent was removed-in vacuo and the black residue was boiled with chloroform and filtered hot. Evaporation of the solvent, trituration with ether and recrystallisation from acetonitrile gave the desired product. Yield 0.63 g (52%), m.p. 161°-162 ° C.

後処理

  1. filtrationfiltered hot
  2. customEvaporation of the solvent, trituration
  3. customwith ether and recrystallisation from acetonitrile

出典と根拠

ORDレコード
ord-cc2ee1dd54d346f69dbe993fe7a9be88
出典データセット
uspto-grants-1995_04
特許番号
US05409943

反応ノート

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