m-Chloroperbenzoic acid → HCID 20077200、化合物

HRID 1654952ノート

反応式

HRID 1654952 の反応式
[CH3:1][O:2][C:3](=[O:17])[CH2:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10](C(=O)C)[CH:11]=2)[CH2:6]1.ClC1C=CC=[C:21]([C:25]([O:27]O)=[O:26])C=1>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:17])[CH2:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:27][C:25](=[O:26])[CH3:21])[CH:11]=2)[CH2:6]1

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 20077196HCID 20077196、化合物

生成物 1

HCID 20077200HCID 20077200、化合物収率 97%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

11.0 g (47.0 mmol) of methyl(5-acetylindan-2-yl)acetate was dissolved in 200 ml of methylene chloride, to which was added 14.6 g (67 mmol) of m-chloroperbenzoic acid and stirred for 4 hours at room temperature, followed by refluxing for 17 hours. The reaction mixture was washed with saturated aqueous sodium bicarbonate and water in this order, dried and then the solvent was removed. The residue was purified by silica gel column chromatography (chloroform) to obtain 11.3 g of an oily product. Yield: 97%

後処理

  1. temperatureby refluxing for 17 hours
  2. washThe reaction mixture was washed with saturated aqueous sodium bicarbonate and water in this order
  3. customdried
  4. customthe solvent was removed
  5. customThe residue was purified by silica gel column chromatography (chloroform)

出典と根拠

ORDレコード
ord-fb7ee56e50bc459fa4fa577f5c76189a
出典データセット
uspto-grants-1995_04
特許番号
US05409956

反応ノート

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