Nitric Acid → 4-(Methylsulfanyl)-2-nitrophenol
反応式
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.[N+:10]([O-])([OH:12])=[O:11]>C(Cl)Cl>[N+:10]([C:7]1[CH:8]=[C:3]([S:2][CH3:1])[CH:4]=[CH:5][C:6]=1[OH:9])([O-:12])=[O:11]参加物
4
実験手順
To a solution of 4-(methylthio)phenol(5.0 g) in methylene chloride (100 mls) was added 30% nitric acid absorbed on silica (9.29 g) and the mixture stirred at room temperature for 3hrs. The mixture was filtered and washed with methylene chloride. The solvent was evaporated and the residue was purified by flash chromatography eluting with ethyl acetate and hexane (15:85 v/v ) to give 2-nitro-4-(methylthio)phenol as an orange solid (2.22 g);
後処理
- customabsorbed on silica (9.29 g)
- filtrationThe mixture was filtered
- washwashed with methylene chloride
- customThe solvent was evaporated
- customthe residue was purified by flash chromatography
- washeluting with ethyl acetate and hexane (15:85 v/v )
出典と根拠
- ORDレコード
- ord-81bed632dbd54875956ae110e783d8c1
- 出典データセット
- uspto-grants-1995_04
- 特許番号
- US05410064
反応ノート
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