Thionyl Chloride → HCID 131718192、化合物

HRID 1655190ノート

反応式

HRID 1655190 の反応式
[C:1]([C:3]1[CH:4]=[N:5][N:6]([C:13]2[C:18]([Cl:19])=[CH:17][C:16]([C:20]([F:23])([F:22])[F:21])=[CH:15][C:14]=2[Cl:24])[C:7]=1[CH:8]=[CH:9][C:10](O)=[O:11])#[N:2].S(Cl)([Cl:27])=O>C1(C)C=CC=CC=1>[C:1]([C:3]1[CH:4]=[N:5][N:6]([C:13]2[C:18]([Cl:19])=[CH:17][C:16]([C:20]([F:23])([F:21])[F:22])=[CH:15][C:14]=2[Cl:24])[C:7]=1[CH:8]=[CH:9][C:10]([Cl:27])=[O:11])#[N:2]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 67858667HCID 67858667、化合物

生成物 1

HCID 131718192HCID 131718192、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

By the method of Example 7, Step A, 0.96 g (0.0026 mole) of 3-[4-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-pyrazol-5-yl]acrylic acid and 1 mL of thionyl chloride were reacted in 20-30 mL of toluene, yielding 0.56 g of 3-[4-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-pyrazol-5-yl]acrylic acid chloride as an oil. The nmr spectrum was consistent with the proposed structure and indicated the product to be primarily the trans acrylic acid derivative.

出典と根拠

ORDレコード
ord-960a30c824454ff288f7e356804bdbe1
出典データセット
uspto-grants-1993_10
特許番号
US05250504

反応ノート

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