m-Chloroperbenzoic acid → HCID 19791188、化合物
反応式
ClC1C=CC=C(C(OO)=[O:9])C=1.[N:12]1([C:18]2[C:23]([Br:24])=[CH:22][N:21]=[C:20]([CH3:25])[CH:19]=2)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>ClCCl>[N:12]1([C:18]2[CH:19]=[C:20]([CH3:25])[N+:21]([O-:9])=[CH:22][C:23]=2[Br:24])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1参加物
4
実験手順
m-Chloroperbenzoic acid (7.3 g) in dichloromethane (100 ml) was added dropwise to a stirred solution of 4 -piperidino-5 -bromo-2 -picoline. After 16 hours, the solution was washed with 10 % aqueous sodium carbonate, dried (K2CO3) and stripped. The residue was chromatographed (silica gel, chloroform:methanol) to give 4 -piperidino-5 -bromo-2 -picoline-N-oxide, 6.79 g, m.p. 115°-6 ° from ether.
後処理
- washthe solution was washed with 10 % aqueous sodium carbonate
- dry with materialdried (K2CO3)
- customThe residue was chromatographed (silica gel, chloroform:methanol)
出典と根拠
- ORDレコード
- ord-390c34398eff40e9adc51209b37b4179
- 出典データセット
- uspto-grants-1993_10
- 特許番号
- US05250527
反応ノート
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