Nitric Acid → HCID 19792129、化合物

HRID 1655465ノート

反応式

HRID 1655465 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:12][C:13](=[O:18])[CH2:14][CH2:15][CH2:16][CH3:17])=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[N+:19]([O-])([OH:21])=[O:20]>C(OC(=O)C)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([N+:19]([O-:21])=[O:20])[C:5]([NH:12][C:13](=[O:18])[CH2:14][CH2:15][CH2:16][CH3:17])=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 19792116HCID 19792116、化合物

生成物 1

HCID 19792129HCID 19792129、化合物

試薬・触媒・溶媒 1

HCID 7918Acetic Anhydride溶媒

実験手順

To a solution of methyl 5-chloro-2-valerylaminobenzoate (13.4 g) in acetic anhydride (10 ml) was added dropwise, while stirring under ice-cooling, fuming nitric acid. The mixture was stirred for one hour at room temperature, then there was added ice water. The mixture was allowed to stand to give crystals. Recrystallization from isopropyl ether afforded pale yellow crystals (9.5 g, 61%), m.p. 84-85° C.

後処理

  1. temperaturecooling
  2. stirringThe mixture was stirred for one hour at room temperature
  3. customto give crystals
  4. customRecrystallization from isopropyl ether afforded pale yellow crystals (9.5 g, 61%), m.p. 84-85° C.

出典と根拠

ORDレコード
ord-d6ae6d71e9d241edbda47ca09678da74
出典データセット
uspto-grants-1993_10
特許番号
US05250554

反応ノート

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