Butylamine → 2-(Butylamino)nicotinonitrile

HRID 1655582ノート

反応式

HRID 1655582 の反応式
[CH:1]1[CH:6]=[N:5][C:4](Cl)=[C:3]([C:8]#[N:9])[CH:2]=1.[CH2:10]([NH2:14])[CH2:11][CH2:12][CH3:13]>C(O)(C)C>[CH2:10]([NH:14][C:4]1[C:3]([C:8]#[N:9])=[CH:2][CH:1]=[CH:6][N:5]=1)[CH2:11][CH2:12][CH3:13]

参加物

4

反応物 2

HCID 8007ButylamineHCID 810792-Chloronicotinonitrile

生成物 1

HCID 126029792-(Butylamino)nicotinonitrile

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

2-Chloronicotinitrile (1.30 g, 9.60 mmol) was refluxed with 3 mL of n-butylamine and 10 mL of isopropyl alcohol overnight. The solvents were removed in vacuo and the residue obtained chromatographed on silica gel eluting with 2:1 hexane/ethyl acetate to give 1.6 g of the title compound.

後処理

  1. customThe solvents were removed in vacuo
  2. customthe residue obtained
  3. customchromatographed on silica gel eluting with 2:1 hexane/ethyl acetate

出典と根拠

ORDレコード
ord-3654888df14242feb8137a91165712be
出典データセット
uspto-grants-1993_10
特許番号
US05250548

反応ノート

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