Sulfuric Acid → 2-(Furan-2-yl)-3-methylbutanoic acid

HRID 1655760ノート

反応式

HRID 1655760 の反応式
C([O:3][C:4](=[O:19])[C:5]([C:14]1[O:15][CH:16]=[CH:17][CH:18]=1)([CH:11]([CH3:13])[CH3:12])C(OCC)=O)C.[OH-].[Na+].S(=O)(=O)(O)O>CS(C)=O>[O:15]1[CH:16]=[CH:17][CH:18]=[C:14]1[CH:5]([CH:11]([CH3:13])[CH3:12])[C:4]([OH:19])=[O:3]

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 536718092-Furyl-2-isopropylmalonic acid diethyl ester

生成物 1

HCID 197908462-(Furan-2-yl)-3-methylbutanoic acid収率 98.2%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

240.6 g (0.9 mol) of 2-furyl-2-isopropylmalonic acid diethyl ester were dissolved in 500 ml of dimethyl sulfoxide, treated with 2000 ml of 2N sodium hydroxide solution and heated to reflux for 2 hours. After cooling, o the reaction mixture was poured into dilute sulfuric acid and extracted exhaustively with ether. The organic extracts were thereafter dried and the solvent was evaporated under reduced pressure, to obtain 148.7 g (98%) of (±) 2-(2-furyl)-3-methyl- butyric acid in the form of a thick yellowish oil.

後処理

  1. temperatureheated
  2. temperatureto reflux for 2 hours
  3. temperatureAfter cooling, o the reaction mixture
  4. extractionextracted exhaustively with ether
  5. customThe organic extracts were thereafter dried
  6. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-b414730056a548e08079aab95ebcceec
出典データセット
uspto-grants-1993_10
特許番号
US05250517

反応ノート

読み込み中…