Dicyclohexylcarbodiimide → 2,4-Dimethyl-4-isopropyl-2-oxazolin-5-one

HRID 1655844ノート

反応式

HRID 1655844 の反応式
[C:1]([NH:4][C:5]([CH3:12])([CH:9]([CH3:11])[CH3:10])[C:6]([OH:8])=[O:7])(=O)[CH3:2].C1(N=C=NC2CCCCC2)CCCCC1>C1COCC1>[CH3:2][C:1]1[O:7][C:6](=[O:8])[C:5]([CH3:12])([CH:9]([CH3:11])[CH3:10])[N:4]=1

参加物

4

反応物 2

HCID 10868DicyclohexylcarbodiimideHCID 2338052-Acetamido-2,3-dimethylbutanoic acid

生成物 1

HCID 146957652,4-Dimethyl-4-isopropyl-2-oxazolin-5-one

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
25 °C

実験手順

2-Acetamido-2,3-dimethylbutyric acid (16 g) is dissolved in THF (200 mL) and dicyclohexylcarbodiimide (DCC, 21.0 g) is added. The mixture is allowed to stir for 16 hours at 25° C. At the end of this time the mixture is filtered and evaporated to dryness. The residue is dissolved in CH2Cl2 (10 mL) and filtered again. Evaporation of the filtrate gives the crude product which is purified by distillation at 0.65 mmHg, having bp 50° C.

後処理

  1. filtrationAt the end of this time the mixture is filtered
  2. customevaporated to dryness
  3. dissolutionThe residue is dissolved in CH2Cl2 (10 mL)
  4. filtrationfiltered again
  5. customEvaporation of the filtrate

出典と根拠

ORDレコード
ord-38b800039dcc41c89b118753c3ec2882
出典データセット
uspto-grants-1993_10
特許番号
US05252539

反応ノート

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