Acetic Acid → HCID 19789780、化合物

HRID 1656107ノート

反応式

HRID 1656107 の反応式
[BH4-].[Na+].[CH2:3]([N:5]1[CH2:17][CH2:16][CH:15]2[CH:7]([NH:8][C:9]3[C:14]2=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH2:6]1)[CH3:4].[C:18](O)(=O)[CH3:19]>>[CH2:3]([N:5]1[CH2:17][CH2:16][CH:15]2[CH:7]([N:8]([CH2:18][CH3:19])[C:9]3[C:14]2=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH2:6]1)[CH3:4]

参加物

4

反応物 3

HCID 176Acetic AcidHCID 4311764Sodium borohydride2 回HCID 19789750HCID 19789750、化合物

生成物 1

HCID 19789780HCID 19789780、化合物

実験手順

NaBH4 (1.08 g) was added under ice-cooling to a solution of 2-ethyl-1,2,3,4,4a,9a-hexahydro-pyrido[3,4-b]indole (1.16 g) in 40 ml of acetic acid. After stirring the solution at room temperature for 4 hrs, additional NaBH4 (0.54 g) was added and the mixture was stirred for 3 hrs. After removal of acetic acid by evaporation, the residue was neutralized with ammonia, extracted with ethyl acetate, washed with brine and dried over magnesium sulfate. The solvent was evaporated off, thereby affording 1.26 g of the title compound as a pale yellow oil.

後処理

  1. stirringthe mixture was stirred for 3 hrs
  2. customAfter removal of acetic acid
  3. customby evaporation
  4. extractionextracted with ethyl acetate
  5. washwashed with brine
  6. dry with materialdried over magnesium sulfate
  7. customThe solvent was evaporated off

出典と根拠

ORDレコード
ord-c47fafc96c4e40bca01b51820d8e3c6e
出典データセット
uspto-grants-1993_10
特許番号
US05252580

反応ノート

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