4-Fluorobenzene-1,2-diamine → N-(5-Fluorobenzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine

HRID 16562

反応式

HRID 16562 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([NH2:9])[CH:3]=1.[N:10]([CH:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15][CH2:14]1)=[C:11]=S>>[F:1][C:2]1[CH:7]=[CH:6][C:5]2[N:8]=[C:11]([NH:10][CH:13]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[CH2:16][CH2:15][CH2:14]3)[NH:9][C:4]=2[CH:3]=1

参加物

3

反応物 2

HCID 1645844-Fluorobenzene-1,2-diamineHCID 213934781-Isothiocyanato-1,2,3,4-tetrahydronaphthalene

生成物 1

HCID 68684304N-(5-Fluorobenzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine

実験手順

The title compound was prepared from 4-fluorophenylenediamine and 1-isothiocyanato-1,2,3,4-tetrahydronaphthalene by Procedure D. The title compound was isolated by column chromatography as the free base and as a mixture of enantiomers (solid, mp 220-221° C.). MS(ES+) m/z 282 ([M+1]+, 100).

出典と根拠

ORDレコード
ord-b9d79720df6a4456b06914d23a4f9fdc
出典データセット
uspto-grants-2010_06
特許番号
US07737167B2

関連ノート

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