Ethyl Acetate → HCID 19787989、化合物

反応式

[C:1]([C:9]1[N:10]=[CH:11][C:12]2[NH:13][C:14]3[C:19]([C:20]=2[C:21]=1[CH2:22][O:23][CH3:24])=[CH:18][C:17]([O:25][Si](C(C)C)(C(C)C)C(C)C)=[CH:16][CH:15]=3)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F-].C([N+](CCCC)(CCCC)CCCC)CCC.C(OCC)(=O)C>O1CCCC1>[C:1]([C:9]1[N:10]=[CH:11][C:12]2[NH:13][C:14]3[C:19]([C:20]=2[C:21]=1[CH2:22][O:23][CH3:24])=[CH:18][C:17]([OH:25])=[CH:16][CH:15]=3)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

実験手順

530 mg of 3-benzoyl-6-triisopropylsilyloxy-4-methoxymethyl-beta-carboline was dissolved in 7.5 ml of absolute tetrahydrofuran and stirred for 0.5 hour under argon at room temperature after adding 1.1 ml of a 1.1 molar tetrabutylammonium fluoride solution in tetrahydrofuran. After adding ethyl acetate, the organic phase was washed with saturated common salt solution, dried and concentrated by evaporation. 315 mg of the title compound was obtained after absorptive precipitation with ethyl acetate/petroleum ether, melting point 258° C.