Hydrochloric Acid → 4-Fluorobenzimidic acid ethyl ester hydrochloride

HRID 1656517ノート

反応式

HRID 1656517 の反応式
[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[ClH:10].[O:11]1CC[CH2:13][CH2:12]1>C(O)C>[ClH:10].[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6](=[NH:7])[O:11][CH2:12][CH3:13])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 145174-Fluorobenzonitrile

生成物 1

HCID 122821594-Fluorobenzimidic acid ethyl ester hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 4-fluorobenzonitrile (50 g) in tetrahydrofuran (300 mL) and ethanol (60.5 mL) at 0° C. was saturated with anhydrous hydrogen chloride gas and the resulting solution was allowed to stand overnight. The solvent was evaporated and the resulting solid was collected and washed with ether to provide ethyl 4-fluorobenzimidate hydrochloride as a white solid (20 g); NMR: 8.27 (m,2), 7.51 (m,2), 4.63 (q,2), 1.47 (t,3).

後処理

  1. customat 0° C.
  2. customThe solvent was evaporated
  3. customthe resulting solid was collected
  4. washwashed with ether

出典と根拠

ORDレコード
ord-c1a6320558b6436bb8ca96d5073c58a1
出典データセット
uspto-grants-1993_10
特許番号
US05254558

反応ノート

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