3-Nitro-4-(2,4-bis(1,1-dimethylpropyl)phenoxy)-pyridine → 3-Amino-4-(2,4-bis(1,1-dimethylpropyl)phenoxy)-pyridine

HRID 1656557

反応式

HRID 1656557 の反応式
[N+:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[O:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]([CH3:21])([CH3:20])[CH2:18][CH3:19])=[CH:13][C:12]=1[C:22]([CH3:26])([CH3:25])[CH2:23][CH3:24])([O-])=O.[H][H]>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[O:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]([CH3:20])([CH3:21])[CH2:18][CH3:19])=[CH:13][C:12]=1[C:22]([CH3:25])([CH3:26])[CH2:23][CH3:24]

参加物

5

反応物 2

HCID 197882323-Nitro-4-(2,4-bis(1,1-dimethylpropyl)phenoxy)-pyridineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 197882333-Amino-4-(2,4-bis(1,1-dimethylpropyl)phenoxy)-pyridine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

3-Nitro-4-(2,4-bis(1,1-dimethylpropyl)phenoxy)-pyridine (6.0 g, 0.017 mol) was dissolved in ethanol (50 mL) and catalytically reduced by hydrogen with Pd/C catalyst at room temperature for 2 hours. The mixture was filtered through filter-cel and the ethanol removed in vacuo to yield the pure product 3-amino-4-(2,4-bis(1,1-dimethylpropyl)phenoxy)-pyridine in 98% recovered yield. Mass spectral and NMR data were consistent with the proposed structure.

後処理

  1. filtrationThe mixture was filtered
  2. filtrationthrough filter-cel
  3. customthe ethanol removed in vacuo

出典と根拠

ORDレコード
ord-d8d9fe1a4ab84ce98e568a9a55c49051
出典データセット
uspto-grants-1993_10
特許番号
US05254592

関連ノート

読み込み中…