化工社化工社 化学情報印刷レポート · 研究参考用
N-Methylmorpholine N-oxide monohydrate → Methyl alpha-(2-formylphenyl)-beta-methoxyacrylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Methylmorpholine N-oxide monohydrate | HCID 2724197 | — |
| 反応物 | Methyl 2-[2-(bromomethyl)phenyl]-3-methoxyprop-2-enoate | HCID 53395349 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | Methyl alpha-(2-formylphenyl)-beta-methoxyacrylate | HCID 53811047 | 67.2% |
反応手順
35.5 g (0.125 mol) of methyl alpha-(2-bromomethylphenyl)-β-methoxyacrylate are dissolved in 500 ml of CCl4. 43.4 g (0.321 mol) of methylmorpholine N-oxide monohydrate are added, and the mixture is refluxed for 20 hours. The solid is filtered of f and the CCl4 phase is washed with water, with 2 N hydrochloric acid and again with water, dried and concentrated. 18.5 g (67%) of product are obtained as a reddish brown oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05254717 |
| 出典データセット | uspto-grants-1993_10 |
| ORD ID | ord-146f12103baa42ee9b84cc65d41ab655 |
| 出典メモ | uspto-grants-1993_10 |