Hydrochloric Acid → HCID 15729196、化合物
反応式
C([NH:4][C:5]1[S:6][C:7]([S:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[CH:8][N:9]=1)(=O)C.O1CCCC1.Cl>C(O)C>[NH2:4][C:5]1[S:6][C:7]([S:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[CH:8][N:9]=1参加物
5
実験手順
A mixture of 2-acetylamino-5-(3-pyridylthio)thiazole (8.5 g) in a mixture of ethanol (160 ml), tetrahydrofuran (50 ml) and aqueous 6N hydrochloric acid (100 ml) was refluxed for 4 hours with stirring. The reaction mixture was concentrated under reduced pressure and the residue was dissolved in water. The solution was adjusted to pH 8.5 using aqueous sodium bicarbonate and the precipitates were collected by filtration, washed with water and dried in vacuo to give 2-amino-5-(3-pyridylthio)thiazole (5.6 g yield: 78.9%). mp: 140°-142° C. IR (Nujol): 3400, 3300, 3125, 1630, 1530, 1490 cm-1
後処理
- temperaturewas refluxed for 4 hours
- concentrationThe reaction mixture was concentrated under reduced pressure
- dissolutionthe residue was dissolved in water
- filtrationthe precipitates were collected by filtration
- washwashed with water
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-d5b461443cf8463e96cad0a68de23eb9
- 出典データセット
- uspto-grants-1993_10
- 特許番号
- US05256675
反応ノート
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