Hydrochloric Acid → 2,2-Diphenyl-2-(2-propynyl)acetaldehyde

HRID 1657272ノート

反応式

HRID 1657272 の反応式
[C:1]1([C:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)([CH2:10][C:11]#[CH:12])[C:8]#N)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH2:25].Cl>O1CCCC1>[C:1]1([C:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)([CH2:10][C:11]#[CH:12])[CH:8]=[O:25])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 108234172,2-Diphenylpent-4-ynenitrileHCID 21226445Aluminium lithium hydride

生成物 1

HCID 107997012,2-Diphenyl-2-(2-propynyl)acetaldehyde

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 2,2-diphenyl-2-(2-propynyl)acetonitrile (1.38 g) and lithium aluminum hydride (0.21 g) in tetrahydrofuran (15 ml) was refluxed for 2 hours. The reaction mixture was poured into cold water, acidified with hydrochloric acid and extracted with diethyl ether. The extract was washed with brine, dried over magnesium sulfate and evaporated in vacuo. The residue was purified by column chromatography on silica gel with a mixture of n-hexane and benzene (1:1) as an eluent to give 2,2-diphenyl-2-(2-propynyl)acetaldehyde (0.46 g).

後処理

  1. temperaturewas refluxed for 2 hours
  2. extractionextracted with diethyl ether
  3. washThe extract was washed with brine
  4. dry with materialdried over magnesium sulfate
  5. customevaporated in vacuo
  6. customThe residue was purified by column chromatography on silica gel with a mixture of n-hexane and benzene (1:1) as an eluent

出典と根拠

ORDレコード
ord-53da709d82214db89488facac587c2c3
出典データセット
uspto-grants-1993_10
特許番号
US05256824

反応ノート

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