Sodium Chloride → HCID 19787485、化合物

HRID 1657280ノート

反応式

HRID 1657280 の反応式
[OH-].[K+].O1CCCC1.[O:8]=[C:9]([CH3:20])[CH2:10][C:11]([CH:17]1[CH2:19][CH2:18]1)([CH:14]1[CH2:16][CH2:15]1)[CH:12]=O.[Cl-].[Na+]>C(OCC)C>[CH:14]1([C:11]2([CH:17]3[CH2:19][CH2:18]3)[CH2:10][C:9](=[O:8])[CH:20]=[CH:12]2)[CH2:16][CH2:15]1

参加物

6

反応物 4

HCID 5234Sodium ChlorideHCID 8028TetrahydrofuranHCID 14797Potassium HydroxideHCID 19787455HCID 19787455、化合物

生成物 1

HCID 19787485HCID 19787485、化合物収率 91.6%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a mixture of 5% aqueous solution of potassium hydroxide (4.7 ml) and tetrahydrofuran (4.7 ml) was added a solution of 4-oxo-2,2-dicyclopropylpentanal (1.88 g) in diethyl ether (9.4 ml). The mixture was heated at 38° C. to 45° C. for 3 hours and cooled. The aqueous layer was saturated with sodium chloride. The mixture was extracted with diethyl ether and the extract was washed with brine, dried over sodium sulfate, and evaporated in vacuo. The residue was purified by distillation under reduced pressure to give 4,4-dicyclopropyl-2-cyclopenten-1-one (1.55 g).

後処理

  1. temperatureThe mixture was heated at 38° C. to 45° C. for 3 hours
  2. temperaturecooled
  3. extractionThe mixture was extracted with diethyl ether
  4. washthe extract was washed with brine
  5. dry with materialdried over sodium sulfate
  6. customevaporated in vacuo
  7. distillationThe residue was purified by distillation under reduced pressure

出典と根拠

ORDレコード
ord-49ef4a14f04d4d5a9d77b0cc27590ba9
出典データセット
uspto-grants-1993_10
特許番号
US05256824

反応ノート

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