1-(3-Chlorophenyl)piperazine → HCID 12414808、化合物

HRID 1657404

反応式

HRID 1657404 の反応式
Cl[CH2:2][CH2:3][C:4]1[C:9](=[O:10])[N:8]2[C:11]([CH3:15])=[CH:12][CH:13]=[CH:14][C:7]2=[N:6][C:5]=1[CH3:16].[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1>C1(C)C=CC=CC=1>[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][N:27]([CH2:2][CH2:3][C:4]3[C:9](=[O:10])[N:8]4[C:11]([CH3:15])=[CH:12][CH:13]=[CH:14][C:7]4=[N:6][C:5]=3[CH3:16])[CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1

参加物

4

反応物 2

HCID 13551-(3-Chlorophenyl)piperazineHCID 46254083-(2-chloroethyl)-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one

生成物 1

HCID 12414808HCID 12414808、化合物収率 34.8%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 2.4 g of 3-(2-chloroethyl)-2,6-dimethy-4H-pyrido[1,2-a]pyrimidin-4-one, 5.9 g of 1-(m-chlorophenyl)piperazine and 25 ml of toluene was refluxed with heating for 30 hours. The reaction mixture was then treated in the same manner as in Example 1, and the obtained crude crystals were recrystallized from isopropyl alcohol to give 1.4 g of the desired compound as pale yellow needles, m.p. 116.5° - 117.5°C.

後処理

  1. temperaturewas refluxed
  2. temperaturewith heating for 30 hours
  3. additionThe reaction mixture was then treated in the same manner as in Example 1
  4. customthe obtained crude crystals
  5. customwere recrystallized from isopropyl alcohol

出典と根拠

ORDレコード
ord-cacede88fdc148cc8f70e8a89c0ca45c
出典データセット
uspto-grants-1976_06
特許番号
US03960863

関連ノート

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