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1-(3-Chlorophenyl)piperazine → 3-[2-(4-m-Chlorophenyl-1-piperazinyl)ethyl]-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(3-Chlorophenyl)piperazine | HCID 1355 | — |
| 反応物 | 3-(2-chloroethyl)-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one | HCID 4625408 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 3-[2-(4-m-Chlorophenyl-1-piperazinyl)ethyl]-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one | HCID 12414808 | 34.8% |
反応手順
A mixture of 2.4 g of 3-(2-chloroethyl)-2,6-dimethy-4H-pyrido[1,2-a]pyrimidin-4-one, 5.9 g of 1-(m-chlorophenyl)piperazine and 25 ml of toluene was refluxed with heating for 30 hours. The reaction mixture was then treated in the same manner as in Example 1, and the obtained crude crystals were recrystallized from isopropyl alcohol to give 1.4 g of the desired compound as pale yellow needles, m.p. 116.5° - 117.5°C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03960863 |
| 出典データセット | uspto-grants-1976_06 |
| ORD ID | ord-cacede88fdc148cc8f70e8a89c0ca45c |
| 出典メモ | uspto-grants-1976_06 |