反应详情

A mixture of 2.4 g of 3-(2-chloroethyl)-2,6-dimethy-4H-pyrido[1,2-a]pyrimidin-4-one, 5.9 g of 1-(m-chlorophenyl)piperazine and 25 ml of toluene was refluxed with heating for 30 hours. The reaction mixture was then treated in the same manner as in Example 1, and the obtained crude crystals were recrystallized from isopropyl alcohol to give 1.4 g of the desired compound as pale yellow needles, m.p. 116.5° - 117.5°C.

1. temperaturewas refluxed
2. temperaturewith heating for 30 hours
3. additionThe reaction mixture was then treated in the same manner as in Example 1
4. customthe obtained crude crystals
5. customwere recrystallized from isopropyl alcohol