Hydrochloric Acid → HCID 21528057、化合物
反応式
[C:1]([C:4]1([O:10][CH2:9]1)[CH2:5][C:6]([OH:8])=[O:7])(=[O:3])[NH2:2].[OH-].[Na+].[C-:13]#[N:14].[Na+].Cl>O>[C:1]([C:4]([OH:10])([CH2:9][C:13]#[N:14])[CH2:5][C:6]([OH:8])=[O:7])(=[O:3])[NH2:2]参加物
6
実験手順
43.5 g (0.3 mol) of the 3-carbamoyl-3,4-epoxybutyric acid was placed in 150 ml of water and 50.2 ml of 5.98 M NaOH solution (0.3 mol) added at 15°C. The pH of the solution was 12.07. 16.2 g of NaCN (0.33 mol) dissolved in 50 ml of water was then added at 15°C. The pH changed to 12.28. The temperature was then raised to 33°-35°C over about 10 min. 6.73 N HCl (approximately 0.3 mol) was then added slowly to maintain the pH at 11. After 27 hrs the solution was assayed by NMR analysis and showed a 101±2 percent yield of the 3-carbamoyl-3-hydroxy-4-cyanobutyric acid salt.
後処理
- additionwas then added at 15°C
- temperatureThe temperature was then raised to 33°-35°C over about 10 min
- temperatureto maintain the pH at 11
出典と根拠
- ORDレコード
- ord-6738c9e40a8d4128b2759c7cf39b1fc3
- 出典データセット
- uspto-grants-1976_06
- 特許番号
- US03960941
反応ノート
読み込み中…