Allyl bromide → Alimadol

HRID 1657536ノート

反応式

HRID 1657536 の反応式
[C:1]1([C:7]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)([O:17][CH3:18])[CH2:8][CH2:9][NH:10][C:11](=O)[C:12](F)(F)F)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:25](Br)C=C.[OH-].[K+]>CC(C)=O>[C:1]1([C:7]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)([O:17][CH3:18])[CH2:8][CH2:9][NH:10][CH2:11][CH:12]=[CH2:25])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 7841Allyl bromideHCID 14797Potassium HydroxideHCID 21534186HCID 21534186、化合物

生成物 1

HCID 176882Alimadol収率 93%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

16.7 g. of N-(3,3-diphenyl-3-methoxypropyl)-trifluoroacetamide, prepared according to Example 4, and 24.2 g. of allyl bromide in 150 ml. of anhydrous acetone are heated to 50°C. and 11.2 g. of powdered potassium hydroxide are added. The mixture is then boiled for 5 minutes and the solvent is distilled off in vacuo. The residue is boiled for one hour with 100 ml. of water and 100 ml. of methanol and is worked up as in Example 4. 13.1 g. of 1,1-diphenyl-1-methoxy-3-allylaminopropane of melting point 45° to 50°C. are obtained, corresponding to a yield of 93% of theory.

後処理

  1. distillationthe solvent is distilled off in vacuo
  2. waitThe residue is boiled for one hour with 100 ml

出典と根拠

ORDレコード
ord-60efb1f5ec024113a75fdb0fceebe1bb
出典データセット
uspto-grants-1976_06
特許番号
US03960960

反応ノート

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