1-Benzyl-4-tert-butyl-piperazine → 1-Tert-butylpiperazine

HRID 1657754

反応式

HRID 1657754 の反応式
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]([CH3:17])([CH3:16])[CH3:15])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[C:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)([CH3:17])([CH3:16])[CH3:15]

参加物

5

反応物 2

HCID 35919371-Benzyl-4-tert-butyl-piperazineHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 35305721-Tert-butylpiperazine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

348.5 g of 1-benzyl-4-tert-butyl piperazine are dissolved in 1200 cc of 99% ethanol and 10 g of a 5% palladium/charcoal catalyst are added to the resulting solution. The solution is subsequently shaken in a hydrogenation apparatus, in a hydrogen atmosphere (1 atmosphere) and at room temperature, until the take up of hydrogen is complete. Filtration is subsequently effected, the filtrate is concentrated by evaporation in a vacuum and the residue is distilled in a vacuum. 1-tert-butyl piperazine is obtained in the form of a colourless oil, having a B.P. of 66°-70° at 12 mm of Hg, which crystallizes upon standing. The crystals have a M.P. of 35°-40°.

後処理

  1. filtrationFiltration
  2. concentrationthe filtrate is concentrated by evaporation in a vacuum
  3. distillationthe residue is distilled in a vacuum

出典と根拠

ORDレコード
ord-cc0c308b59904e31a7e2a086d164837b
出典データセット
uspto-grants-1976_06
特許番号
US03962248

関連ノート

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