Thionyl Chloride → 2-Azido-2-methoxyacetyl chloride
反応式
[N:1]([CH:4]([O:8][CH3:9])[C:5](O)=[O:6])=[N+:2]=[N-:3].S(Cl)([Cl:12])=O>>[N:1]([CH:4]([O:8][CH3:9])[C:5]([Cl:12])=[O:6])=[N+:2]=[N-:3]参加物
3
反応条件
- 温度
- 80 °C
実験手順
A solution of 2-azido-2-methoxyacetic acid (4.2 g.) in thionyl chloride (10 ml.) is heated in an oil bath maintained at 80°C. for 20 minutes. After cooling to room temperature, the mixture is evaporated in vacuo to remove excess thionyl chloride and the residue is distilled to yield 2-azido-2-methoxyacetyl chloride (2.26 g.) as a water-white liquid (b.p. 64°-66°C./27 mm.).
後処理
- temperatureAfter cooling to room temperature
- customthe mixture is evaporated in vacuo
- customto remove excess thionyl chloride
- distillationthe residue is distilled
出典と根拠
- ORDレコード
- ord-10fdb16b88914a318645158beba07bf6
- 出典データセット
- uspto-grants-1976_06
- 特許番号
- US03962224
反応ノート
読み込み中…