Nitric Acid → HCID 54734201、化合物

HRID 1658099ノート

反応式

HRID 1658099 の反応式
[N+:1]([O-:4])(O)=[O:2].[CH2:5]([N:7]1[C:17]2[C:12](=[CH:13][C:14]([CH3:18])=[CH:15][CH:16]=2)[C:11]([OH:19])=[CH:10][C:8]1=[O:9])[CH3:6]>C(O)(=O)C>[CH2:5]([N:7]1[C:17]2[C:12](=[CH:13][C:14]([CH3:18])=[CH:15][CH:16]=2)[C:11]([OH:19])=[C:10]([N+:1]([O-:4])=[O:2])[C:8]1=[O:9])[CH3:6]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 546963011-Ethyl-4-hydroxy-6-methylquinolin-2(1H)-one

生成物 1

HCID 54734201HCID 54734201、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Concentrated nitric acid (2.5 ml; d, 1.42) was added to a suspension of 1-ethyl-4-hydroxy-6-methyl carbostyril. (1.82g. 0.009 mole) in glacial acetic acid (10 ml) and the mixture warmed to 100°C. The solid dissolved and the 3-nitro derivative immediately solidified as a yellow solid. After cooling the solid was filtered, washed well with water and dried in vacuo over P2O5, m.p. 192°-4°C; (Found; C, 58.16; H, 5.02; N, 11.29; C12H12N2O4 requires; C, 58.06; H, 4.87; N, 11.29%).

後処理

  1. dissolutionThe solid dissolved
  2. temperatureAfter cooling the solid
  3. filtrationwas filtered
  4. washwashed well with water
  5. dry with materialdried in vacuo over P2O5, m.p. 192°-4°C

出典と根拠

ORDレコード
ord-efc6b5c2afbe4fe68b4e1462f1f6b8a0
出典データセット
uspto-grants-1976_06
特許番号
US03962445

反応ノート

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