Acetic Acid → HCID 12883909、化合物

HRID 1658119ノート

反応式

HRID 1658119 の反応式
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:11]=[CH:12][C:13]3[C:19](=[O:20])[C:18]([C:21]([OH:23])=[O:22])=[CH:17][NH:16][C:14]=3[N:15]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].S(OCC)(O[CH2:28][CH3:29])(=O)=O.C(O)(=O)C>C(=O)([O-])[O-].[Na+].[Na+]>[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:11]=[CH:12][C:13]3[C:19](=[O:20])[C:18]([C:21]([OH:23])=[O:22])=[CH:17][N:16]([CH2:28][CH3:29])[C:14]=3[N:15]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 6163Diethyl SulfateHCID 128507552-(4-Acetyl-1-piperazinyl)-5,8-dihydro-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid

生成物 1

HCID 12883909HCID 12883909、化合物

試薬・触媒・溶媒 1

HCID 10340Sodium Carbonate溶媒

実験手順

To a solution of 0.45 g of 2-(4-acetyl-1-piperazinyl)-5,8-dihydro-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid in 30 ml of sodium carbonate was added two 0.5 ml portions of diethyl sulfate with stirring at room temperature. After the completion of the reaction the mixture was neutralized with acetic acid. The precipitate resulted was collected and recrystallized from dimthylformamide to yield 0.4 g of the product, m.p. 298° - 300°C.

後処理

  1. customAfter the completion of the reaction the mixture
  2. customThe precipitate resulted
  3. customwas collected
  4. customrecrystallized from dimthylformamide

出典と根拠

ORDレコード
ord-bc368523f23642bbb9c0d7feac13cecf
出典データセット
uspto-grants-1976_06
特許番号
US03962443

反応ノート

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