反応式
[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])[CH2:3][CH2:2]1.C=O.[C:18](=[O:21])([O-])[O-].[K+].[K+].[CH2:24](O)[CH3:25]>>[CH2:24]([O:21][CH2:18][N:1]1[CH2:6][CH2:5][CH:4]([CH2:7][NH:8][C:9](=[O:15])[O:10][C:11]([CH3:12])([CH3:14])[CH3:13])[CH2:3][CH2:2]1)[CH3:25]参加物
5
実験手順
To a stirred solution of tert-butyl (piperidin-4-ylmethyl)carbamate (7.0 g, 33 mmol) in ethanol (19 mL), paraformaldehyde (1.2 g, 39 mmol) and potassium carbonate (5.4 g, 39 mmol) were added at ambient temperature. The mixture was stirred at ambient temperature for 4 h. The mixture was filtered and the filter cake was washed with ethanol (50 mL). The volatile components were removed by evaporation to give the title compound 8.9 g (quant.) as a white powder.
後処理
- filtrationThe mixture was filtered
- washthe filter cake was washed with ethanol (50 mL)
- customThe volatile components were removed by evaporation
出典と根拠
- ORDレコード
- ord-ea6c31155be54dbcb207cf0d781a0ce8
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07737163B2
関連ノート
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