Chloroacetyl chloride → 2-Chloro-N-(2-methyl-4-sulphamoylphenyl)-acetamide

反応式

[CH3:1][C:2]1[CH:8]=[C:7]([S:9](=[O:12])(=[O:11])[NH2:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[Cl:13][CH2:14][C:15](Cl)=[O:16]>>[Cl:13][CH2:14][C:15]([NH:4][C:3]1[CH:5]=[CH:6][C:7]([S:9](=[O:12])(=[O:11])[NH2:10])=[CH:8][C:2]=1[CH3:1])=[O:16]

参加物

反応物 2

HCID 6577Chloroacetyl chloride

HCID 1430374-Amino-3-methylbenzene-1-sulfonamide

生成物 1

HCID 215288492-Chloro-N-(2-methyl-4-sulphamoylphenyl)-acetamide

実験手順

2-methyl-4-sulphamoylaniline (18,6 g) and α-chloroacetyl chloride (30g) were refluxed together 30 min. and the mixture worked up as in Example 2(a) to yield 11 g, m.p. 193°-194°

後処理

customto yield 11 g, m.p. 193°-194°

出典と根拠

ORDレコード: ord-af1623bdbf9c4a9ea3f1a88efd2e675b
出典データセット: uspto-grants-1976_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US03963706

反応ノート

読み込み中…