Sodium Hydroxide → HCID 21529154、化合物

HRID 1658318ノート

反応式

HRID 1658318 の反応式
[CH3:1][O:2][C:3]1[CH:20]=[CH:19][C:6]([CH2:7][S:8][C:9]2[C:10]([C:15]([O:17]C)=[O:16])=[N:11][CH:12]=[CH:13][CH:14]=2)=[CH:5][CH:4]=1.[OH-].[Na+]>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][S:8][C:9]2[C:10]([C:15]([OH:17])=[O:16])=[N:11][CH:12]=[CH:13][CH:14]=2)=[CH:19][CH:20]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 14277622Methyl 3-[[(4-methoxyphenyl)methyl]thio]-2-pyridinecarboxylate

生成物 1

HCID 21529154HCID 21529154、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 3 g. of methyl 3-(p-methoxybenzylthio)picolinate in 50 ml. of ethanol is added 10 ml. of 20% aqueous sodium hydroxide solution and the mixture is warmed on a steam bath for two hours. The alcohol is evaporated off and the residue is cooled and acidified with dilute hydrochloric acid. The precipitate is filtered off, washed with water, dried and recrystallized from methanol to give 3-(p-methoxybenzylthio)picolinic acid, m.p. 170°-172°C.

後処理

  1. customThe alcohol is evaporated off
  2. temperaturethe residue is cooled
  3. filtrationThe precipitate is filtered off
  4. washwashed with water
  5. customdried
  6. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-f3ca85deaeb0490bbe97aa24c2ed272e
出典データセット
uspto-grants-1976_06
特許番号
US03963733

反応ノート

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