3-Trifluoromethylisobutyranilide → Ethyl-N-(3-trifluoromethylphenyl)isobutyrimidate

HRID 1658671

反応式

HRID 1658671 の反応式
[B-](F)(F)(F)F.[CH3:6][CH2:7][O+](CC)CC.[F:13][C:14]([F:28])([F:27])[C:15]1[CH:16]=[C:17]([CH:24]=[CH:25][CH:26]=1)[NH:18][C:19](=[O:23])[CH:20]([CH3:22])[CH3:21]>ClCCl>[CH2:6]([O:23][C:19](=[N:18][C:17]1[CH:24]=[CH:25][CH:26]=[C:15]([C:14]([F:27])([F:28])[F:13])[CH:16]=1)[CH:20]([CH3:22])[CH3:21])[CH3:7]

参加物

4

反応物 2

HCID 1372643-TrifluoromethylisobutyranilideHCID 2723982Triethyloxonium tetrafluoroborate

生成物 1

HCID 21528116Ethyl-N-(3-trifluoromethylphenyl)isobutyrimidate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

Add a solution of 5.0 g. (0.03 moles) of triethyloxonium fluoborate in 13 ml. of dichloromethane to a solution of 7.3 g. (0.03 moles) of 3'-trifluoromethylisobutyranilide in 60 ml. of dichloromethane and reflux for 20 hours. Remove 50 ml. of dichloromethane and add 150 ml. of dry ether to precipitate out the product of this example as its fluoborate salt, m.p.=95°-100°C.

後処理

  1. additionAdd a solution of 5.0 g
  2. customRemove 50 ml
  3. additionof dichloromethane and add 150 ml
  4. customof dry ether to precipitate out the product of this example as its fluoborate salt, m.p.=95°-100°C.

出典と根拠

ORDレコード
ord-9ca430cf61254486bff17b0e0f712086
出典データセット
uspto-grants-1976_06
特許番号
US03965176

関連ノート

読み込み中…