HCID 21505599、化合物 → HCID 21525672、化合物

HRID 1658807ノート

反応式

HRID 1658807 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:23])[CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH:16]=[C:15]([C:18]3[O:19][CH:20]=[CH:21][N:22]=3)[CH2:14][CH2:13]2)=[CH:4][CH:3]=1>[Pd].C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:23])[CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([C:18]3[O:19][CH:20]=[CH:21][N:22]=3)[CH2:14][CH2:13]2)=[CH:4][CH:3]=1

参加物

4

反応物 1

HCID 21505599HCID 21505599、化合物

生成物 1

HCID 21525672HCID 21525672、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A 0.32 g. portion of 3,6-dihydro-α-(p-fluorophenyl)-4-(2-oxazolyl)-1(2H)-pyridinebutanol, prepared as described in Example 15, is dissolved in 10 ml. of ethanol and 0.1 g. of palladium on carbon catalyst is added. The mixture is reduced at room temperature and pressure for 4 hours and then filtered. The filtrate is evaporated giving an oil which solidifies to a white solid. This solid is recrystallized twice from acetonitrile, m.p. 99°-100°C.

後処理

  1. dissolutionis dissolved in 10 ml
  2. customis reduced at room temperature
  3. filtrationfiltered
  4. customThe filtrate is evaporated
  5. customgiving an oil which
  6. customThis solid is recrystallized twice from acetonitrile, m.p. 99°-100°C.

出典と根拠

ORDレコード
ord-de1a2b649bd7474c912c0e76e4af0c36
出典データセット
uspto-grants-1976_06
特許番号
US03966748

反応ノート

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